Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06175598

Enrollment

Registered

2023-12-19

Start date

2023-12-01

Completion date

2023-12-07

Last updated

2023-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric ALL, Surgery

Brief summary

The goal of this observational study is to conducted a comprehensive analysis of the factors contributing to redo- Pull-through surgery for constipation recurrence in Children who are suffering from Hirschsprun' s disease (HSCR) and its allied disorders (ADHD) . The main question\[s\] it aims to answer are: 1. Our study focused on the treatment and prognosis of these conditions, drawing upon 16 years of patient data and clinical experiences 2. What are the key risk factors affecting the prognosis of recurrent constipation patients undergoing repeat PT?

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. Patients admitted to the department of pediatric surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2005 and December 2021; 2. HSCR and ADHD patients admitted due to constipation recurrence and requiring redo-PT.

Exclusion criteria

1. Patients undergoing staged surgeries or undergoing internal sphincterotomy; 2. Patients with concomitant severe congenital anomalies such as Down syndrome; (3) Patients with incomplete postoperative follow-up data after redo-PT.

Design outcomes

Primary

Measure	Time frame	Description
Participants with redo-pull-through surgery for recurrent constipation	1990-2023	After utilizing the terms Hirschsprung and Redo pull-through in searches across PubMed and Web of Science for references published between 1990 and 2023, and subsequent removal of duplicate and incomplete documents, we compiled clinical information from the remaining literature. This compilation facilitated a review of relevant literature on the causes of redo-PT for recurrent constipation, enabling an assessment of classification types, which we categorized into five groups: Incomplete Resection of Affected Intestinal Segments (IRAIS), Acquire Aganglionosis (AA), Intestinal Dysmotility (ID), Anastomotic Complications (AC), and Intestinal Neurodevelopmental Impairment (INI).
Participants with and without postoperative complications	through study completion, an average of 33 year	Group the data by gender, age groups, surgical techniques, and surgical approaches. Then, calculate the number of cases with and without postoperative complications

Countries

China

Outcome results