Respiratory Distress Syndrome, Adult, Respiratory Failure
Conditions
Keywords
Abdominal pressure, Overdistension
Brief summary
The goal of this pilot interventional no-profit study is to evaluate airway pressure, esophageal pressure and variations in lung volume distribution with EIT in mechanically ventilated patients admitted to our UTI with respiratory failure after the application of an abdominal weight and resulting increase of intra-abdominal pressure.
Interventions
PROCEDUREApplication of abdominal weight
Application of variable weight on the abdomen to reach a 5 mmHg increase in IAP
Sponsors
University of Padova
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Invasive mechanical ventilation in acute respiratory failure (PaO2/FiO2 \<300 mmHg) * Need of PEEP trial * Need of urinary catheter (used to measure IAP)
Exclusion criteria
* Contraindication to EIT use * Pacemaker or other metal device in thoracic region * Contraindication to abdominal weight placement * Surgical or traumatic incision on the abdomen * Severe abdominal hypertension * Esophageal diseases that counterindicate naso-gastric tube placement * Severe hemodynamic instability (norepinephrine \> 0.1 mcg/kg/min; dobutamine or dopamine \> 5 mcg/kg/min; epinephrine every dosage) * Severe obesity (BMI \> 35 kg/m2) * Need of \> 7 kg weight to reach 5 mmHg IAP increase
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Variation of lung volume distribution | through study completion, an average of 1 year | TID % |
| Variation of airway pressure | through study completion, an average of 1 year | cmH2O |
| Variation of esophageal pressure | through study completion, an average of 1 year | cmH2O |
Countries
Italy
Contacts
Primary ContactPaolo Persona, MD, PhD
Outcome results
None listed