Thrombophilia
Conditions
Keywords
Thrombophilia, direct oral anticoagulants, DOAC, Apixaban, Rivaroxaban, Dabigatran, Hemostasis tests
Brief summary
Direct oral anticoagulants (DOAC) are anticoagulant molecules that act either directly on factor Xa (Apixaban, Rivaroxaban) or on factor IIa (Dabigatran). AODs interfere with most coagulation tests, especially those performed by chronometric technique. For this reason, part of the thrombophilia workup (protein S, search for lupus anticoagulants, antithrombin for patients on dabigatran) cannot be performed on DOACs at the HUS. Recent studies have highlighted the effectiveness of activated charcoal to adsorb DOACs in order to perform certain hemostasis tests.
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Adult subject (≥ 18 years of age) * Blood sample already analyzed in a usual way in the laboratory as part of the care * Subject not objecting to the reuse of his or her medical data for scientific research purposes.
Exclusion criteria
\- Insufficient sample
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interference or not of activated charcoal in the measurement of protein S, antithrombin, and in the search for lupus anticoagulants. | Through study completion, an average of 6 months | This study compares the results of two diagnostic techniques (Thrombophilia work-up under direct oral anticoagulants (DOACs)), one using activated charcoal versus another not using it |
Countries
France
Contacts
Primary ContactAgathe HERB, PharmD
Outcome results
None listed