Knee Arthrosis
Conditions
Brief summary
A trial to investigate the safety and efficacy of SVF for the treatment of knee arthrosis. Patients will undergo a single liposuction to obtain the SVF. The SVF will then be isolated and frozen in our laboratory. The SVF will then be injected up to 2 times into the fat pad of the patient's knee.
Detailed description
Stromal Vascular Fraction (SVF) from adipose tissue is increasingly being used in the clinic for a variety of conditions (skin disorders, joint pain, etc.). SVF is a collective term for cells that can be obtained from liposuction fat. These cells can be separated from the fat by mechanical processing of the liposuction fat combined with an additional centrifugation. Despite the fact that enough SVF can be isolated after such a liposuction for multiple treatments (\>3), our research group has found a way to safely freeze SVF without significant loss of SVF cells. In this way, a patient would only have to undergo one liposuction and associated anesthesia to be able to obtain multiple SVF treatments.
Interventions
PROCEDUREInjection of SVF in fat pad of the knee
Knee fat pad injection with SVF at orthopaedics/physical medicine outpatient clinic
Sponsors
University Hospital, Ghent
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Legal capacity * Osteochondral lesions * Inflammatory complaints * (Peri)tendinitis or tendinopathies and ligamentous injuries * Impingement complaints * Arthrofibrosis * Anterior knee pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the safety of SVF injections after cryo preservation | 1 year | The patient will complete the KOOS questionnaire (Knee Injury and Osteoarthritis Outcome Score) on several timepoints. |
Countries
Belgium
Contacts
Primary ContactBernard Depypere, MD
Backup ContactJessie De Kinder
Outcome results
None listed