Carotid Artery Stenosis
Conditions
Brief summary
Objective: To evaluate the technical performance of a novel cascaded wave imaging technique compared to plane wave imaging for blood flow imaging in patients with and without carotid artery stenosis. Study design: Observational, feasibility study in a total of 10 patients with and 10 patients without a hemodynamic significant carotid artery plaque. Intervention (observational): all participants will undergo a carotid ultrasound measurement including conventional duplex ultrasound and ultrasound based flow imaging using plane waves and cascaded waves.
Interventions
DIAGNOSTIC_TESTConventional duplex
Conventional carotid duplex measurement
DIAGNOSTIC_TESTUltrasound-based flow imaging using plane wave imaging
Ultrasound-based flow imaging using plane wave imaging
DIAGNOSTIC_TESTUltrasound-based flow imaging using cascaded wave imaging
Ultrasound-based flow imaging using cascaded wave imaging
Sponsors
Netherlands Organisation for Scientific Research
Radboud University Medical Center
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Capacitated adult male or female (≥18 years old); * Informed consent form understood and signed; * Recent conventional duplex measurement of the carotid artery confirming either the absence or presence of a plaque
Exclusion criteria
* Hampered carotid blood flow imaging during conventional duplex/doppler measurements due to near to total carotid occlusion at the side of interest or a calcified plaque; * History of radiation at the head-neck area; * Participating in another clinical study, interfering on outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2D velocity vector fields obtained by plane wave and cascaded wave imaging of the carotid artery | After study completion, average of one year |
Secondary
| Measure | Time frame |
|---|---|
| Velocity vector fields obtained from plane wave and cascaded wave imaging will be obtained and compared | After study completion, average of one year |
| Blood-flow related parameters, including vector complexity and vorticity, will be calculated from 2D velocity fields. | After study completion, average of one year |
| Signal-to-noise ratio obtained from plane wave and cascaded wave imaging will be obtained and compared for different vessel depths | After study completion, average of one year |
| Cross-correlation maps of plane wave and cascaded wave imaging will be obtained and compared for different vessel depths | After study completion, average of one year |
| Spatiotemporal blood flow profiles obtained with plane wave, cascaded wave and conventional duplex ultrasound will be compared to assess the correlation between these techniques | After study completion, average of one year |
Countries
Netherlands
Outcome results
None listed