Aging, Brain Disease, Cognitive Decline, Sleep Disturbance
Conditions
Keywords
Ageing, Sleep disturbances, Cognition, Brain health, Longevity
Brief summary
Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.
Detailed description
Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.
Interventions
None listed
Sponsors
The University of Hong Kong
Chinese University of Hong Kong
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
55 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* Chinese old adults are the ones who are over 60 years of chronological age. * Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score \>5.
Exclusion criteria
* History of bipolar disorders or psychosis. * History of major neurological deficits, including stroke, transient ischemic attack or brain tumor. * Unable to participant magnetic resonance imaging (MRI) scanning.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complex attention will be measured by the Attention Network Test (ANT) | Baseline | The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0. |
| Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI) | Baseline | Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire |
| Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA) | Baseline | The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Memory and learning will be measured by the Word list learning test (WLLT) | Baseline | Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition. |
| Executive functions will be measured by the category verbal fluency test (CVFT) | Baseline | On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds |
| The levels of Aβ40 and Aβ42 will be measured by saliva analysis | Baseline | saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection. |
Countries
Hong Kong
Outcome results
None listed