Effect of Individualized PEEP on Postoperative Pulmonary Complication in Bariatrics

Effect of Individualized High Positive End-expiratory Pressure on Postoperative Pulmonary Rate in Laparoscopic Bariatric Surgeries

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06168162

Enrollment

Registered

2023-12-13

Start date

2023-10-01

Completion date

2025-05-01

Last updated

2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bariatric Surgery Candidate, Mechanical Ventilation Pressure High

Keywords

ventilation

Brief summary

Ventilation with low tidal volume and high PEEP (positive end expiratory pressure) has been shown to improve oxygenation in patients with ARDS (acute respiratory distress syndrome). In obese patients undergoing laparoscopic bariatric surgeries, the risk of postoperative pulmonary complications (PPCs) increases significantly with general anesthesia. Previous studies have shown that protective lung ventilation strategies could improve intraoperative oxygenation and lung mechanics. In this study would compare the effect of optimum individualized high PEEP versus standard PEEP - on postoperative pulmonary complications

Interventions

OTHERtitated PEEP to best static compliance

the Intraoperative PEEP will be titrated to best static compliance for each patient

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients were eligible for participation if the met the following criteria * Age between 18 and 60 years old. * Body mass index \> 40 * Laparoscopic bariatric elective surgery under general anesthesia. * ARISCAT (Assess Respiratory Risk in Surgical Patients in Catalonia) score ≥ 45 . ARISCAT score is a clinically practical seven-factor scoring system to assess the risk of a composite PPC.

Exclusion criteria

* Previous lung surgery * ASA status III or IV. * Moderate to severe obstructive or restrictive lung disease . * Persistant intraoperative hemodynamic instability . * Need for postoperative mechanical ventilation

Design outcomes

Primary

Measure	Time frame	Description
postoperative pulmonary complication	postoperative 10 days after surgery	pneumonia-atelactasis-bronchospasm-respiratory failure

Secondary

Measure	Time frame	Description
Pulmonary functions test	postoperative 1st , 3rd and 5th day	This test includes these values :FVC (forced vital capacity ) FEV1( forced expiratory volume in one sec ) FEV1% and FVC%

Countries

Egypt

Contacts

Primary Contactwessam selima, MD

w.z.selima@med.asu.edu.eg+201001958858

Backup Contactghada sharafeldin, MSc

ghadasharaf.92@gmail.com+201159296642

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026