Diurnal
Conditions
Brief summary
To evaluate the influence of time of day on the circulating concentrations of various biochemical markers in healthy men
Interventions
OTHERDiurnal variation
Venous blood samples were obtained under standardized circumstances from 24 healthy young men every third hour through 24 hours, nine time points in total.
Sponsors
University of Copenhagen
Bispebjerg Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Medically healthy * Normal sleep-wake pattern
Exclusion criteria
* acute or chronic medical diseases * had worked nightshifts the last 14 days before the study * transatlantic traveling the last 14 days before the study * had been smoking the last 14 days before the study * had an irregular sleep-wake pattern, * didn't sleep 7-8 hours pr night * were extreme morning- or evening types, * had plasma hemoglobin \< 8.0 mmol/L * ody mass index (BMI) \<18.5 kg/m2 or \>24.9 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| hematology parameters | 24 hours | Composite measurement of hematological measurements |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Levels of Glucagon | 24 hours |
| Plasma levels of GLP-1 | 24 hours |
| Plasma levels of GIP | 24 hours |
| Plasma levels of c-peptide | 24 hours |
| Plasma levels of glucose | 24 hours |
Outcome results
None listed