Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients

Comparison Between the Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients Undergoing Endoscopic Urological Surgeries: A Randomized Controlled Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06165679

Enrollment

112

Registered

2023-12-11

Start date

2023-12-20

Completion date

2025-06-30

Last updated

2025-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic Instability

Brief summary

Data comparing prilocaine vs bupivacaine in equipotent doses in the elderly are lacking; therefore, the study will compare the effect of prilocaine vs bupivacaine on hemodynamics in spinal anesthesia for geriatric patients undergoing endoscopic urological surgeries

Interventions

DRUGPrilocaine

The patients will receive a single injection of spinal anesthesia using prilocaine plus fentanyl

DRUGBupivacaine

The patients will receive a single injection of spinal anesthesia using Bupivacaine plus fentanyl

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 65 years old and above. * Both genders. * Patients scheduled to undergo endoscopic urological surgeries. * ASA I and II class.

Exclusion criteria

* Patient refusal. * Known local anesthetic (LA) allergy. * Bleeding disorders. * Skin lesions or infections at site of needle insertion. * Hypertensive patients. * Patients candidate for transurethral resection of the prostate * ASA III and VI class

Design outcomes

Primary

Measure	Time frame	Description
Hypotension	Till 30 minutes after spinal anesthesia.	Incidence of hypotension from local anesthetic injection

Secondary

Measure	Time frame	Description
Use of vasopressor drugs	Until the patient will have no lower limbs motor weakness assessed up to 6 hours after spinal anesthesia	Total doses of vasopressor drugs used for hypotension treatment

Other

Measure	Time frame	Description
Mean and systolic arterial blood pressure values	Until the patient will have no lower limbs motor weakness assessed up to 6 hours after spinal anesthesia	Mean and systolic arterial blood pressure values after spinal anesthesia
Heart rate	Until the patient will have no lower limbs motor weakness assessed up to 6 hours after spinal anesthesia	Heart rate after spinal anesthesia

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026