Exercise Fatigue
Conditions
Keywords
Cycling, Proteomics, Grand tour
Brief summary
This project aims to identify the effect of a 3-week grand tour (e.g. Tour de France) on physiological markers and the blood proteome in world-class cyclists.
Detailed description
Blood samples will be collected in world-tour cyclists in the fasted state (i) before, (ii) on the first resting day, (ii) on the second resting day, and (iv) on the final day of the Tour de France. Samples collected before and on the final day will be analyzed by proteomics, while sample from all timepoints will be assessed for specific cytokines to identify physiological markers of fatigue. In addition, questionnaires will be used to evaluate subjective feelings of fatigue and appetite.
Interventions
OTHERTour de France
Participating in the Tour de France as cyclist
Sponsors
KU Leuven
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Cyclist participating in the Tour de France
Exclusion criteria
* Younger than 18years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum proteome abundance of cyclists during Tour de France | Start of the Tour de France (day 0) - last day of the Tour de France (day 23) | Change in serum proteome between start and end of Tour de France |
| Serum GDF15 (Growth and differentiation factor 15) concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Serum GDF15 throughout the grand tour |
| Blood haemoglobin concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Haematological profile of cyclists |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum ghrelin concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Blood ghrelin |
| White blood cell concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | White blood cells |
| Serum free BDNF (brain-derived neutrophic factor) concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Blood BDNF |
| Serum FGF21 (fibroblast growth factor 21) concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Blood FGF21 |
| Serum Leptin concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Serum leptin |
| Red blood cell concentration | Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23) | Red blood cells |
Countries
Belgium
Outcome results
None listed