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Quantification of Internal Training Load

Quantification of Internal Training Load: Toward the Prediction of the Distribution of Hypertrophy

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06164249
Acronym
QUADRATURE
Enrollment
36
Registered
2023-12-11
Start date
2024-01-29
Completion date
2024-05-19
Last updated
2023-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertrophy, Muscle, Resistance Training

Keywords

Muscle activation, Muscle volume, Muscle stress, Muscle mass

Brief summary

The aim of this study is to determine whether the distribution of internal load predicts the distribution of muscle hypertrophy among hamstring heads after a 10-week resistance exercise program. The hypothesis is that the distribution of internal muscle load among the hamstring is related to the distribution of muscle hypertrophy.

Detailed description

It is well accepted that muscle stress (mechanical and/or metabolic) is the major way to induce muscle hypertrophy. While this link between muscle stress and hypertrophy is pivotal is sport training, prevention and rehabilitation, it remains poorly understood. To date, the only indirect evidence of relationship of muscle stress and muscle hypertrophy is the similar patterns (from independent studies) between muscle damage and hypertrophy within quadriceps (i.e., rectus femoris (RF) \> vastus (VL) = vastus medialis VM), hamstring, and triceps surae. However, muscle damage is an indirect proof of muscle mechanical stress. With the quantification of internal muscle load, it is interesting to determine whether the muscle that receives the larger stress exhibits the larger hypertrophy.

Interventions

OTHERstrength training

Strength training, three times a week, during nine weeks.

Sponsors

Université de Nantes
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)

Masking description

Investigator is blind. Participants know in which group they are as each group is composed of no exercise (control), Nordic hamstring exercise (Nordic), or Deadlift exercise (Deadlift)

Intervention model description

Three independent groups : * Control (no strengthening) * Nordic (strengthening in Nordic Hamstring exercise) * Deadlift (strengthening in Deadlift exercise)

Eligibility

Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

* No history of lower limb injury * No chronic pathology associated with a long term care

Exclusion criteria

* Individual enrolled in a research study

Design outcomes

Primary

MeasureTime frameDescription
Muscle volume10 weeksHypertrophy
Internal training load10 weeksMagnitude and onset/offset of muscle activation

Secondary

MeasureTime frameDescription
Maximal strength Nordic10 weeksMaximal strength during the Nordic exercise
Maximal strength Deadlift10 weeksMaximal strength during the Deadlift exercise

Contacts

Primary ContactLilian LACOURPAILLE, Doctor
lilian.lacourpaille@univ-nantes.fr+33670807473
Backup ContactTitouan MORIN, MsC
titouan.morin@univ-nantes.fr+33645226957

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026