Recurrent Miscarriage
Conditions
Keywords
Fibroids, Polyps, Adhesions, Adenomyosis, Endometrial blood flow
Brief summary
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
Detailed description
High-quality studies including several meta-analyses have proven the association between congenital uterine anomalies and recurrent miscarriages. Nevertheless, there are limited studies evaluating the impact of acquired uterine anomalies on recurrent miscarriages. This prospective observational study will aim to compare the prevalence of acquired uterine anomalies between the study group and the control group. The secondary aim will be to compare the Endometrial morphological features like endometrial volume, endometrial and sub-endometrial vascularity between the two groups
Interventions
DIAGNOSTIC_TEST3D Ultrasound scan with power Doppler angiography
The study group and the control group will be offered a 3D ultrasound scan as a part of this trial.
Sponsors
University Hospitals of Derby and Burton NHS Foundation Trust
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Women between the age group of 18-40 years 2. Women who have had 2 or more pregnancy losses before 24 weeks of gestation - Study group. 3. Women who can provide documented informed consent 4. Women with proven fertility with at least one child - Control group
Exclusion criteria
1\. Women with previous history of miscarriage/ extreme preterm delivery (before 28 weeks of gestation) will be excluded from the Control group.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Acquired Uterine Anomalies | 24 months | Primary outcome will be to compare the prevalence of acquired uterine anomalies (estimated as the proportion of anomalies diagnosed on 3D pelvic ultrasound) between study group and control group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endometrial thickness | 24 months | measured by ultrasound (in mm) |
| Endometrial volume | 24 months | measured by 3D ultrasound (in ml) |
| Endometrial blood flow indices (vascularisation index, flow index and vascularisation flow index) | 24 months | All three indices as measured by 3D ultrasound using VOCAL software |
Contacts
Primary ContactProf Kanna Jayaprakasan
Backup ContactKate Threapleton
Outcome results
None listed