Arterial Stiffness, Endothelial Dysfunction
Conditions
Brief summary
This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only \ 50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.
Interventions
OTHERAcute submaximal exercise
30 min of treadmill running at 70% of the participants maximal oxygen consumption
Sponsors
Towson University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-29 years of age; healthy male and female; Physically inactive, defined as participation in less than 20 min of continuous endurance exercise on fewer than 2 days/week; Recreationally active, defined as participation in 30 min/day of moderate-intensity cardiovascular activity on greater than 4 days/week; Highly active- defined as performing 30-60 min of moderate- to vigorous-intensity endurance exercise greater than 5 days/week.
Exclusion criteria
* currently pregnant, previously diagnosed coronary heart disease or congenital heart disease, serum total cholesterol \>200 mg/dl, low-density lipoprotein cholesterol \>130 mg/dl, high-density lipoprotein cholesterol \< 35 mg/dl, fasting glucose \>100 mg/dl, systolic blood pressure \> 130 mmHg, diastolic blood pressure \>90 mmHg, and BMI \>30 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endothelial function | Baseline and 60 min post-exercise | flow-mediated dilation |
| arterial stiffness | Baseline and 60 min post-exercise | augmentation index |
Countries
United States
Outcome results
None listed