Biliary Atresia
Conditions
Brief summary
Biliary atresia (BA) is a rare biliary tree disease with a high incidence in eastern Asia. Kasai operation is a standard treatment for BA, and studies have shown that timely Kasai operation is crucial for better outcomes. The Kasai operation can be performed as either an open or laparoscopic technique. This study aimed to compare the differences in anesthetic management between the two surgical groups. Herein, we compared the outcomes of infants with BA who underwent the open and laparoscopic Kasai surgery.
Detailed description
Biliary atresia is (BA) a rare biliary tree disease. This disease, which is usually found in infancy is characterized by biliary inflammation and obliteration. The incidence variate from 1 in 5000 to 20000. However, high prevalence rate up to 1 in 5-10,000 was comparatively noted in eastern Asia, especially in Japan and Taiwan. Biliary atresia can be treated by Kasai operation ( Kasai portoenterotomy) or liver transplantation. In the previous study, 60% of biliary atresia patients after receiving Kasai portoenterostomy could have better liver prognosis.The timing of Kasai operation is also crucial, increased age of surgery had negative influence in the long-term follow up. Traditionally, Kasai portoenterostomy was performed by open surgery. As the progression and popularity of minimally invasive surgery, laparoscopic Kasai was first introduced in 2002 and then performed in many countries. However, the advantage of laparoscopic Kasai seems still controversial due to many indicative outcomes as early jaundice clearance, native liver survival (NLS) and liver transplantation rate within 1 year after the Kasai operation even adhesions prevention seems no better maybe worse in laparoscopic group.But in our hospital, no statistically significant differences were observed for hospital stay and outcomes (including early jaundice clearance rate, episodes of cholangitis, and 2-year native liver survival rate) between the open and the laparoscopic Kasai operations.Even the better operation view was noted in laparoscopic group but operation time seems almost all prolonged in laparoscopic one compared to open one, that makes excessive fluid infusion and hypothermia easily found in laparoscopic group . However, no hypothermia and laryngeal edema were noted in our hospital compare to previous study
Interventions
PROCEDURElaparoscopic
laparoscopic
Sponsors
Taichung Veterans General Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* children who had undergone Kasai portoenterostomy between January 2011 and December 2021
Exclusion criteria
* severe congenital heart disease requiring surgical treatment, * reoperation, * a diagnosis of non-biliary atresia, * incomplete medical records.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fluid intake_1 | through study completion, an average of 1 year | intravenous fluid infusion during the operation ( ml) |
| fluid intake_2 | through study completion, an average of 1 year | transfusion volume during the operation (ml) |
| output_1 | through study completion, an average of 1 year | urine output |
| output_2 | through study completion, an average of 1 year | blood loss (ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| total days of hospitalization | through study completion, an average of 1 year | total hospital days |
| total days of admission to ICU | through study completion, an average of 1 year | total ICU days |
| surgery-related outcomes_1 | through study completion, an average of 1 year | postoperative day 1 liver function ( GOT, GPT,bilirubin in the postoperative day 1) |
| respiratory outcomes_1 | through study completion, an average of 1 year | extubation time ( duration between extubation and end of the surgery) |
| surgery-related outcomes_3 | through study completion, an average of 1 year | cholangitis ( cholangitis needes antibiotics treatment) |
| surgery-related outcomes_4 | through study completion, an average of 1 year | 6-month bilirubin clearance rate ( bilirubin below standard rate at 6-month) |
| surgery-related outcomes_2 | through study completion, an average of 1 year | native liver survival time ( duration before liver transplantation) |
| respiratory outcomes_2 | through study completion, an average of 1 year | EtCO2 |
| respiratory outcomes_3 | through study completion, an average of 1 year | peak airway pressure |
| surgery duration of the surgery | through study completion, an average of 1 year | total surgery time |
Outcome results
None listed