Calculosis
Conditions
Keywords
calculosis, calculi, endourologia
Brief summary
Retrospective and prospective study on patients suffering from nephrolithiasis who undergo minimally invasive surgery of the upper excretory system; correlation between the phenotypic and genotypic aspects of the patients and the stone pathology treated with an endoscopic surgical approach.
Detailed description
Clinical data will be collected from patients suffering from kidney stones before and after surgery, in order to demonstrate how the endoscopic approach can not only be effective in treating kidney stones but also reduce operative complications. These data will be collected in a database in order to be able to perform statistical analyzes useful for demonstrating our theory. Furthermore, data from the surgery will be collected regarding the endoscopic instruments used and the intraoperative findings (site, size, appearance of the stone), degree of calcification of the renal papillae. All this in order to improve the therapeutic approach to patients suffering from stones and reduce the risk of recurrence over time through the identification of genetic expression patterns that predispose to the expression of the stone phenotype.
Interventions
OTHERObservation of patients suffering from kidney stones who undergo endoscopic surgery
Clinical data will therefore be acquired through a collection of medical history, physical examination, blood chemistry and instrumental test reports;
Sponsors
IRCCS San Raffaele
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subjects suffering from kidney stones or tumors of the upper excretory tract \>= 18 years * signature of informed consent
Exclusion criteria
* subjects \< 18 years * presence of mental or physical disability that may prevent the patient from answering the questionnaires.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical data | Baseline and after 6 months | Medical history: patient's medical history, past surgical history, family medical history, social history, allergies, and medications; physical examination: vital signs, temperature examination, blood pressure, pulse, and respiratory rate blood chemistry and instrumental test reports: Serum PSA levels, conventional imaging |
| Eating habits | Baseline and after 6 months | Eating habits through an ad-hoc eating habits questionnaire |
| Prostatic Function | Baseline and after 6 months | Prostatic Function through the International Prostatic Symptoms Score questionnaire, IPSS, Scoring 0 -7, 0-7 mild symptoms, 8-19 moderate symptoms, 20-35 severe symptoms. |
Countries
Italy
Contacts
Primary ContactAndrea Salonia, MD
Backup ContactAlessia d'Arma, MSc
Outcome results
None listed