Spine Disease
Conditions
Brief summary
Analysis of MRI advanced techniques in degenerative spinal disease. The main questions it aims to answer are: * Can we assess microstructural integrity of compressed nerve roots in degenerative spinal disease * What are the image biomarkers affected by disease * How they evolve with disease progression and treatment
Interventions
DIAGNOSTIC_TESTMRI advanced techniques
Participants will be submitted to MRI studies at diagnosis, during disease evolution and after treatment. Data collected will be analysed by two different neuroradiologists using advanced techniques.
Sponsors
Universidade Nova de Lisboa
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 50 and 85 years * Diagnosis of spinal disease by clinical and imagiological criteria * More than 3 months duration of disease * Ability to give consent * Fluent portuguese speaker
Exclusion criteria
* Previous spine surgery * Spinal instability * Neurological disease that might interfere with walking * Known orthopedic conditions that causes significant gait impairment * Dementia or development disorder with cognitive impairment * Inability to give consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ODI - Oswestry Disability Index | 18 months | Measured using the ODI scale (range 0 - 50) |
| Lumbar Pain Intensity | 18 months | Measured using the Numeric Pain Rating Scale (range: 0 - 10 ) |
Countries
Portugal
Contacts
Primary ContactNuno A.R. Cristino, M.D.
Outcome results
None listed