Hydrogen-Rich Water and Exercise-Related Biomarkers in Men and Women Over 50 Years

The Effects of Drinking Hydrogen-rich Water for 6 Weeks on Exercise-related Biomarkers in Men and Women Over 50 Years Following Resistance Training Program: a Randomized Controlled Pilot Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06163287

Acronym

HYDRORES

Enrollment

Registered

2023-12-08

Start date

2023-10-01

Completion date

2024-03-31

Last updated

2024-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Brief summary

The study investigates the impact of consuming hydrogen-rich water over a six-week period on exercise-related biomarkers among individuals aged over 50, both men and women, who undergo a resistance training program. This research aims to discern the potential benefits of hydrogen-infused water consumption concerning exercise-related markers in an aging demographic post-resistance training.

Interventions

DIETARY_SUPPLEMENTSupplement

Dietary supplement containing molecular hydrogen

DIETARY_SUPPLEMENTPlacebo

Inert substance

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

50 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 50 - 65 years (at least 50% would be over 60 years) * Body mass index 18.5 - 29.9 kg/m2 * Free of major chronic diseases or acute disorders * Resistance exercise naïve (no resistance traiing during 6 months before study commences)

Exclusion criteria

* History of dietary supplement use during the 4 weeks before study commences * Unwillingness to return for follow-up analysis

Design outcomes

Primary

Measure	Time frame	Description
36-Item Short Form Health Survey	Change from baseline 36-Item Short Form Health Survey total score at 6 weeks	Short Form Health Survey total score, minimum and maximum possible score of between 0 and 100, with higher scores mean better outcome

Secondary

Measure	Time frame	Description
Grip strength	Change from baseline grip strength at 6 weeks	Muscular strength generated by one's forearm muscles
Myoglobin	Change from baseline serum myoglobine at 6 weeks	Level of myoglobin in serum
Pittsburgh Sleep Quality Index	Change from baseline Pittsburgh Sleep Quality Index score at 6 weeks	Pittsburgh Sleep Quality Index score, a score ranging from 0 to 3, with 3 indicating the greatest dysfunction
Dehydroepiandrosterone	Change from baseline serum dehydroepiandrosterone at 6 weeks	Level of dehydroepiandrosterone in serum

Countries

Serbia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026