Lower Limb Injury, Osteosarcoma, Outcome, Pediatric
Conditions
Brief summary
Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.
Detailed description
Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (\>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.
Interventions
Retrospective analysis
Sponsors
Changye Zou
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
1. Diagnosed lower limb osteosarcoma patients under the age of 14; 2. Performing tumor resection treatment in our hospital; 3. There is complete clinical registration data available.
Exclusion criteria
1. Not undergoing surgical treatment in our hospital; 2. Age older than 14 years old; 3. No available clinical registration data or lost follow-up patients; 4. Non lower limb osteosarcoma patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival rate (OS) | 2000-2019 | Oncological outcomes |
| Progression-Free Survival rate (PFS) | 2000-2019 | Oncological outcomes |
| Local recurrence rate(LRR) | 2000-2019 | Oncological outcomes |
| Metastasis rate | 2000-2019 | Oncological outcomes |
| Final limb-salvage and amputation rate | 2000-2019 | Oncological outcomes |
| Prosthesis survival rate | 2000-2019 | Functional outcomes |
| Musculoskeletal Tumor Society (MSTS) score | 2000-2019 | Functional outcomes |
| Complications | 2000-2019 | Functional outcomes |
Countries
China
Outcome results
None listed