Influence of Pupillary Behavior During Eye Surgery on Morphological and Functional Outcome

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06160960

Enrollment

500

Registered

2023-12-07

Start date

2017-10-09

Completion date

2024-10-01

Last updated

2023-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract, Corneal Disease, Vitreous Disorder

Keywords

Cataract, refractive surgery, vitrectomy

Brief summary

Pupillary movement during eye surgery can be a challenge for eye surgeons. Despite the risk of intraocular lens damage and malpositioning due to mechanical manipulation1, iris manipulation may lead to a significant elevation of cytokines in the aqueous humor and an increase of postoperative inflammation2, 3. Iris damage is also known to lead to an increase of prostaglandin production which will not only lead to an increase of inflammation but also has an impact on intraoperative miosis4. This leads to the assumption that postoperative inflammation can be related to intraoperative pupillary movements due to the same leading cause of an increase of inflammatory mediators. Tracking intraoperative pupillary movements might therefore be a helpful tool for the prediction of postoperative PCME and could have an impact on therapeutic decisions after surgery.

Interventions

OTHEROCT Scan, Video of pupil movement, video of toric lens

A picture of the central macular area is taken, video of pupil movment, video of toric lens rotation.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 120 Years

Healthy volunteers

Yes

Inclusion criteria

* presence of significant cataract, * written consent. * presence of other ocular conditions requiring surgery such as: degenerative corneal disease, retinal conditions (i.e. macular pucker)

Exclusion criteria

\- reasons for poor video quality (such as poor red reflex due to abnormal anatomy)

Design outcomes

Primary

Measure	Time frame	Description
pupillary movement	during surgery	Analyzing the extend of pupil movement during cataract surgery
IOL rotation	Video taken immediately postoperative and 2-4 weeks postoperative	The rotation of the IOL directly after surgery and a 2-4 weeks postoperative when the second eye is operated.
retinal thickness	at baseline and 2-4 weeks postoperative	OCT Scan to measure retinal thickness at baseline and 2-4 weeks after surgery

Countries

Austria

Contacts

Primary ContactYosuf El-Shabrawi, MD

yosuf.El-Shabrawi@kabeg.at+43 463 538-32403

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026