Epilepsy, Major Depressive Disorder
Conditions
Brief summary
Optimizing treatments in mental health requires an easy to obtain, continuous, and objective measure of internal mood. Unfortunately, current standard-of-care clinical scales are sparsely sampled, subject to recency bias, underutilized, and are not validated for acute mood monitoring. The recent shift to remote care also requires novel methods to measure internal mood. Recent advances in computer vision have allowed the accurate quantification of observable speech patterns and facial representations. The continuous and objective nature of these audio-facial behavioral outputs also enable the study of their neural correlates. Here, the investigators hypothesize that video-derived audio-facial behaviors have discrete neural representations in the limbic network and can provide a critical set of reliable longitudinal estimates of mood at low cost across home and clinic settings.
Interventions
DEVICEIntracranial electrodes
Surgically-implanted intracranial electrodes.
Sponsors
Stanford University
National Institute of Mental Health (NIMH)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age range between 18 and 65 * Major depressive disorder (MDD) in a current major depressive episode diagnosed with the Mini-International Neuropsychiatric Interview (MINI) * No medical or surgical contraindication to electrode implantation * Patient capable of understanding the scope of our project or signing informed consent independently.
Exclusion criteria
* Diffuse epilepsy involving several lobes of the brain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative Audio-Facial Change | 5 minutes | Quantitative percent change in each audio-facial feature before and after direct electrical stimulation at each site. |
| Quantitative Mood Change | 5 minutes | Quantitative percent change in Immediate Mood Scaler (IMS) after direct electrical stimulation at each site compared to a baseline period before sham. The minimum score on the IMS is 7 and the maximum is 154, with lower scores reflecting more negative mood states. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between Audio-Facial and Mood Change | 5 minutes | Quantitative audio facial changes will be compared to quantitative changes in mood at each site by means of correlation and binary comparisons. |
| Qualitative Mood Change | 5 minutes | Qualitative articulation of mood (participants freely articulate mood after direct electrical stimulation at each site) and speech transcripts will be analyzed for ratio of positive and negative valence words. |
Countries
United States
Outcome results
None listed