Sickle Cell Disease
Conditions
Brief summary
Sickle cell disease (SCD) refers to a group of hemoglobinopathies that include mutations in the gene encoding the beta subunit of hemoglobin. Within the umbrella of SCD, many subgroups exist, namely sickle cell anemia (SCA), hemoglobin SC disease (HbSC), and hemoglobin sickle-beta-thalassemia (beta-thalassemia positive or beta-thalassemia negative). Several other minor variants within the group of SCDs also, albeit not as common as the varieties mentioned above. It is essential to mention the sickle cell trait (HbAS), which carries a heterozygous mutation and seldom presents clinical signs or symptoms. Sickle cell anemia is the most common form of SCD
Interventions
DIAGNOSTIC_TESTurinary endothelin 1
assesment of endothelin 1 in urinary sample
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* The patients fulfilling all the following criteria will be included: * Patients with sickle cell disease in the age range of 1-18years.
Exclusion criteria
* Patients diagnosed to have coexistent renal disease before the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| renal affection in sickle cell patients | 1 year | assessment of urinary endothelin 1 as a marker of renal impairment in sickle cell patients |
Countries
Egypt
Contacts
Primary ContactEsraa A Quenawey, resident
Backup ContactAlzahraa A Ahmed, professor
Outcome results
None listed