Cavitation, Invasive Breast Cancer, Perfusion
Conditions
Keywords
Contrast-enhanced ultrasound, ultrasound combined with microbubbles, Invasive ductal carcinoma of breast
Brief summary
Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).
Detailed description
patients with IBC were selected from the breast surgery department of our hospital. To induce an enhanced perfusion effect, IBC tumors were treated with SonoVue® microbubbles (MBs) stimulated by ultrasound, with a mechanical index (MI) of 0.2-0.3; 1 mL of SonoVue® MBs were injected at 3.5-min intervals three times for a USMB treatment lasting 10 min. The contrast-enhanced ultrasound (CEUS) parameters peak intensity (PI), area under the curve (AUC), and perfusion area were used to evaluate the changes in blood perfusion.
Interventions
PROCEDUREultrasound combined with microbubbles
IBC tumors were treated with microbubbles (MBs) stimulated by ultrasound
Sponsors
Beijing Friendship Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Invasive Breast Cancer * patients scheduled to undergo surgical resection * maximum lesion diameter \< 4 cm * age over 18 years
Exclusion criteria
* patients with allergies to SonoVue® * patients with severe cardiopulmonary insufficiency, * patients who had already received neoadjuvant chemotherapy * pregnant women * individuals with mental illness * Patients who refused to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in peak intensity (PI) | 15 minutes after the USMB procedure | PI represents the quantitative scale of the highest average concentration of microbubble (MB) in the region of interest (ROI); thus, a larger PI corresponds to a higher concentration of MB in the ROI. |
| area under the curve (AUC) | 15 minutes after the USMB procedure | AUC represents the total amount of MB passing through the ROI during perfusion; thus, a larger AUC corresponds to greater perfusion in the ROI. |
| percentage increase in the perfusion area (%) of tumor | 15 minutes after the USMB procedure | The percentage increase in the perfusion area (%) was calculated as follows: (perfusion area after the USMB procedure - perfusion area before the USMB procedure) × 100%/perfusion area before the USMB procedure. The greater percentage increase of perfusion area (%), the more significant the improvement of blood perfusion. |
Countries
China
Contacts
Primary ContactYunyun Dong, MS
Outcome results
None listed