Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
Conditions
Brief summary
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: * Will weaning with neurally adjusted ventilatory assist (NAVA) mode ventilation result in shorter ventilator day than synchronised intermittent mandatory ventilation (SIMV) mode? * Will weaning with NAVA mode ventilation result in shorter paediatric intensive care unit (PICU) length of stay than SIMV mode? Participants will be randomised to NAVA or SIMV group for weaning from mechanical ventilation, then PICU outcomes from both groups will be collected, analysed and compared.
Interventions
PROCEDURENAVA
weaning from mechanical ventilator using neurally adjusted ventilatory assist
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* all critically ill children admitted to PICU
Exclusion criteria
* failure to obtain informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ventilator day | immediately after extubation | number of days patients receive mechanical ventilation |
| PICU length of stay | immediately after PICU discharge | number of days patients remain in PICU |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| asynchrony index | 20-minute period randomly captured from the day of extubation | asynchronous breaths divided by total breaths in 20 minutes |
Countries
Thailand
Outcome results
None listed