Fertility Issues
Conditions
Keywords
IMSI, SpermSlow, Sperm selection, ICSI outcome, Sibling-oocytes study
Brief summary
In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes. The methods include the selection of the optimal spermatozoa based on its morphology by IMSI, together with its physiological function of binding to HA by Spermslow (SS). The current study compared a group of ET after sperm selection by IMSI with SS to a group of ET after sperm selection by IMSI-only without SS, and to a mixed ET group where two embryos were transferred, one after IMSI-only and the other one after IMSI with SS.
Interventions
PROCEDURESperm selection by IMSI
Intracytoplasmic morphologically selected sperm injection (IMSI) is a sperm selection method used in intracytoplasmic sperm injection (ICSI)
PROCEDURESperm selection by IMSI and spermslow
Intracytoplasmic morphologically selected sperm injection (IMSI) is a sperm selection method used in intracytoplasmic sperm injection (ICSI) + spermslow
Sponsors
Assuta Medical Center
Tel Aviv University
Meir Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
females ages 38 or younger retrieval of at least 5 mature oocytes and fresh ejaculate samples
Exclusion criteria
frozen embryos surgically extracted sperm preparations embryo-biopsy cycles
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy and delivery rates | Within up to 10 month from treatment | Pregnancy and delivery rates |
Countries
Israel
Outcome results
None listed