Sinus Floor Augmentation
Conditions
Brief summary
The goal of this clinical trial is to compare the expression of multiple genes related to bone regeneration in maxillary bone after being grafted with a commonly used biomaterial supplemented or not with a combination of hyaluronic acid and polynucleotides.
Interventions
PROCEDUREMaxillary sinus floor augmentation
Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone + polynucleotides and hyaluronic acid
Sponsors
Universidad de Granada
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Split-mouth design: each patient receives both treatment options at the same time in right and left sinuses
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Totally edentulous maxilla or Kennedy class I in the upper jaw. * Less than 5 mm of residual crestal bone to the maxillary sinus. * Need for the replacement of teeth with dental implants.
Exclusion criteria
* Sinus pathology (sinusitis, mucocele, cysts). * Heavy smokers (\>10 cigarettes/day). * Previous long-term (\>3 months) use of drugs known to affect bone metabolism, such as bisphosphonates.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transcriptome analysis | 6 months | Transcriptome analysis of a sample of the regenerated bone will be performed 6 months after grafting immediately before implant placement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sinus floor height change | 6 months | CBCT scans will be performed after the sinus floor elevation and 6 months later before implant placement to calculate vertical bone height change |
Countries
Spain
Outcome results
None listed