Gynecologic Cancer, Organoid
Conditions
Brief summary
This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.
Detailed description
Explore the construction and maintenance of a large-scale queue of gynecological tumor organoids. Beijing Daxiang Technology Co., Ltd. provides corresponding technical support and chip design. Gynecological oncology center provides tumor samples, clinical information, and pathological support, and biological sample library provides technical support, storage space, and quality management.
Interventions
OTHERconstruction of organoids from gynecological tumor
organoids construction
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Inclusion criteria
1. Age of 18 or older, an informed consent form is provided; 2. The preoperative tumor burden assessment and intraoperative researcher team believe that sampling is feasible; 3. Having relevant requirements for sample library storage; 4. Surgical treatment at Peking Union Medical College Hospital.
Exclusion criteria
1. Unable to meet all inclusion criteria; 2. The research team considers any situations or considerations that may hinder normal pathological assessment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Construction of BioBank | one year | BioBank including organoids banks, tissue banks, PDX banks, immune cell banks, and primary banks from other tissue sources |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Drug sensitivity detection based on organoids banks | one year | Exploring drug sensitivity detection in gynecological tumors based on organoid libraries |
| Exploring the molecular mechanism based on organoids banks | one year | Exploring the molecular mechanism of gynecological tumor pathogenesis based on organoid banks |
Outcome results
None listed