Diet During Pregnancy
Conditions
Keywords
Pregnancy, Newborn, Vegetalization, Food
Brief summary
Reducing consumption of foods of animal origin in favor of more plant-based diets is a major environmental, public health and economic challenge. Data on the health effects of highly vegetalized diets are available only in adults. Few studies report the effect of the level of vegetalization of the maternal diet during pregnancy on the mother's health, and the development and health of the child. The VEGALIM project aims to describe the level of vegetalization of pregnant women's diets and the nutritional quality of their diets early in pregnancy (first trimester) and late pregnancy, and to explore the potential effects on their plasma lipid profile that may impact on their health during pregnancy and the health of the newborn.
Interventions
We will obtain a global index of vegetalization of the diet (the Plant based Diet Index: PDI) from data obtained using semi-quantitative questionnaires on food frequency (Food Frequency Questionnaire (FFQ)) validated on the national ELFE cohort (French Longitudinal Study from Childhood (https://www.elfe-france.fr)) and completed by women in the 1st trimester of pregnancy (T1) and at delivery.
OTHERCollection of 4 mL maternal blood
One tube collection of 4 mL maternal blood in the first trimester and at delivery.
Sponsors
Nantes University Hospital
UMR 1280 PHAN
INRAE - CRESS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
: * Pregnant women consulting the CEMAFOER at the Nantes University Hospital for pregnancy monitoring * Gestational age between 11 and 13 AW +6 days * Understanding French
Exclusion criteria
* Patients under 18 years of age * Patient who objected to being included in the study * Patient with cognitive problems that prevent her from answering questionnaires
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characterizing the levels of plant-based food consumption at the beginning of pregnancy (at the end of the first trimester of pregnancy) based on the completion of the Food Frequency Questionnaire (FFQ, scale from 0 to 6 ; 0 being the worst outcome) | 25 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Study the evolution of the vegetation score between the 1st and 3rd trimester of pregnancy | 6 months |
| Study changes in diet quality between the 1st and 3rd trimesters of pregnancy | 6 months |
| Studying the association between vegetarian diets in the first trimester of pregnancy and pregnancy outcomes (such as prematurity, birth weight, maternal pathologies not present at the time of inclusion (gestational diabetes, pre-eclampsia, etc.). | 6 months |
| Study the association between diet quality in the first trimester of pregnancy and pregnancy outcomes (such as prematurity, birth weight, maternal pathologies not present at the time of inclusion (gestational diabetes, pre-eclampsia, etc.). | 6 months |
| Study the association between the vegetalization of the diet and the lipid profile of women in the 1st trimester and at childbirth. | 6 months |
| Study the association between diet quality and lipid profiles of women in the 1st trimester and at childbirth. | 6 months |
| Study the association between the vegetalization of the diet and the total fatty acid status of women in the 1st trimester and at childbirth. | 6 months |
| Study the association between diet quality and total fatty acid status in women at 1st trimester and at childbirth. | 6 months |
| Identify other biological markers, such as vitamins, that may be impacted by a change in diet, and study the influence of diet quality on these potential plasma markers of patient and of Umbilical cord blood plasma. | 6 months |
| Study the association between diet quality and the lipid profile of umbilical cord blood at delivery (T3). | 6 months |
Countries
France
Contacts
CONTACTNorbert Winer, MD, PHD
PRINCIPAL_INVESTIGATORNorbert Winer, MD, PHD
Nantes University Hospital
STUDY_DIRECTORVeronique Ferchaud-Roucher, PhD
UMR 1280 PHAN
Outcome results
None listed