Rehabilitation
Conditions
Keywords
Blood flow restriction, Aerobic exercise, Frailty, Elderly
Brief summary
Background:Frailty is most often defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes. Exercise intervention including aerobic exercise training has been proven to be effective in improving aerobic capacity and frail condition in elderly. Recently a novel training method using blood flow restriction (BFR) combined with aerobic exercise has shown positive effects on muscles strength and physical function in healthy elderly. This training method only required lower exercise intensity compared with traditional aerobic exercise to observe improvement. However, it is still unclear whether aerobic exercise training combined with BFR could also improve aerobic capacity and physical function in frail older adults. Therefore, the aim of this study will be to investigate the effect of aerobic exercise combined with BFR on cardiopulmonary function and functional activities in frail older adults. Method: This study will be an assessor-blind randomized controlled trial.Participants aged over 65 years old with more than one item positive of Fried frailty phenotype assessment results will be recruited from the hospital and nearby communities. The participants will be randomly assigned to one of two training groups, aerobic exercise with BFR and only aerobic exercise. The exercise will be executed 30 minutes/session, three sessions/week for six weeks. Cardiopulmonary function and performance of functional activities will be assessed at pre-training, 3 weeks after training, post-training, and 3- and 6-week follow-up.
Interventions
aerobic exercise combined with blood flow restriction for 18 sessions
OTHERaerobic exercise
aerobic exercise for 18 sessions
Sponsors
National Cheng Kung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* more than one positive item of Fried frailty phenotype assessment * able to walk more than 8 meters independently * can understand and follow more than three-step order
Exclusion criteria
* severe hypertension (\>160/100 mmHg) * cardiovascular disease, such as myocardial infarction, New York Heart Association class III or IV heart failure, pulmonary hypertension * deep vein thrombosis or peripheral vascular disease * peripheral neuropathy due to diabetes * neuromuscular diseases, such as stroke, Parkinson's disease, etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Timed up and go test | Before training | This test measure the time taken by an individual to stand up from a chair , walk 3 meters, turn, walk back to the chair, and sit down |
| Lower extremity muscle strength | Before training | Use an hand-held dynamometer to measure bilateral lower limb muscle strength |
| Pulmonary function | Before training | Pulmonary function includes tidal volume, vital capacity, forced vital capacity, and forced expiratory volume in one second |
| Walking speed | Before training | Test the gait speed under preferred and maximum speed walking |
| 2 minutes step test | Before training | Number of steps completed in 2 min |
| 6 minutes walking test | Before training | Record the distance walked in 6 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | Before training | Use Inbody 270 to measure skeletal muscle mass of the whole body and the four extremities |
Countries
Taiwan
Contacts
Primary ContactPei-Yun Lee, PhD
Outcome results
None listed