Evaluation of the Elasticity of the Mitral Valve

Evaluation of the Elasticity of the Mitral Valve Chordae by Uniaxial Traction in the Context of Mitral Valve Regurgitation With a Comparison of the Results: Mitral Valve Prolapse vs Restriction of Mitral Valve Movement

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06153563

Enrollment

Registered

2023-12-01

Start date

2021-10-18

Completion date

2025-03-31

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mitral Valve Disease

Keywords

Mitral valve, mitral valve chords, elasticity, Young's modulus, mitral valve histology

Brief summary

There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen human tissues. The objective is to determine mechanobiological and histological characteristics of the mitral valve chords in living humans, as well as to compare differences in elasticity in different groups (Group A: patients with mitral valve prolapse versus Group B: patients with restrictive ischemic mitral valve).

Detailed description

The prospective study will be conducted on 20 patients, who will be selected consecutively without randomization. The inclusion and exclusion criteria are determined. The harvested tissue will not be frozen and will kept in natural conditions as close as possible.

Interventions

OTHERData collection on patient history and intraoperative results.

Data collection on patient history and intraoperative results.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to No maximum

Healthy volunteers

Inclusion criteria

All patients programmed for mitral valve replacement who have more than 45 years old

Exclusion criteria

* Patients with mitral calcification * Mitral valve rheumatic disease * Mitral valve infections * Redo surgery on the mitral valve

Design outcomes

Primary

Measure	Time frame	Description
Maximum value of Young's modulus	Hour 1	Comparison of elasticity difference between the two groups

Secondary

Measure	Time frame	Description
First histological evaluation	Hour 1	Determine the histological characteristics of living humans

Countries

France

Contacts

Primary ContactAndranik PETROSYAN, MD

andranik.petrosyan@chu-st-etienne.fr(0)477829505

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026