Histamine
Conditions
Brief summary
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
Interventions
DRUGPlacebo
Oral placebo
DRUGH1 blockade: Telfast: 180mg Fexofenadine
H1 blockade: oral blockade with 180mg Fexofenadine
BEHAVIORALResistance training
Resistance training: lower body exercise
Sponsors
Research Foundation Flanders
University Ghent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Parallel groups
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * 18-45 years * Not to medium physically active
Exclusion criteria
* Smoking * Chronic disease * High blood pressure * Supplement or medication intake * Seasonal allergies * Vegetarian / vegan * Resistance trained
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal dynamic strength of leg press, bench press, bicep curl and leg curl | Before and after the 10 weeks of resistance training | Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl |
| Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) | Before and after the 10 weeks of resistance training | Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) |
| Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) | Before and after the 10 weeks of resistance training | Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) |
| Muscle volume | Before and after the 10 weeks of resistance training | Change in muscle volume |
| Muscle fiber hypertrophy in muscle biopsies | Before and after the 10 weeks of resistance training | Change in muscle fiber hypertrophy in muscle biopsies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting heart rate | Before and after the 10 weeks of resistance training | Chance in Resting heart rate |
| Blood pressure (systolic and diastolic) | Before and after the 10 weeks of resistance training | Chance in Blood pressure (systolic and diastolic) |
Countries
Belgium
Contacts
Primary ContactWim Derave, Professor
Outcome results
None listed