Scansys, Pentacam, Keratoconus, Subclinical Keratoconus
Conditions
Keywords
Scansys, Pentacam, Keratoconus, subclinical keratoconus
Brief summary
Comparison of corneal topography based on oct OCT principle (CASIA2) with Pentacam and Scheimpflug-based biomechanical devices (Corvis ST) in screening and diagnosing keratoconus; and evaluation of the consistency with Pentacam in measuring corneal parameters (such as curvature and thickness).
Interventions
morphological and biomechanical parameters of corneal were obtain by CASIA2, Pentacam and Corvis ST
Sponsors
Tianjin Eye Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. Best corrected visual acuity (BCVA) ≥ 20/20; 2. No other eye diseases except myopia and astigmatism; 3. The cornea was transparent, and there was no cloud or pannus;
Exclusion criteria
1. The presence of ocular diseases other than myopia and keratoconus; 2. Ocular trauma; 3. Previous ocular surgery; 4 Patients were required to stop wearing soft contact lenses for at least 2 weeks and rigid contact lenses for at least 4 weeks before examination; 6. Pregnant and lactating women;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| screening and diagnosis ability | one year | Evaluate the sensitivity and specificity of parameters measured by CASIA2, Pentacam in diagnosing keratoconus using Receiver operating characteristic curves (ROC), and compare the Ectasia Screening Similarity（ESS）and D-value diagnostic efficacy using Area under the ROC curve (AUROC). Use the Delong test to compare the accuracy of various parameters in diagnosing early keratoconus. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement consistency | one year | The independent sample T-test is used to compare inter- group differences in baseline data. Use independent sample T-test and One-way ANOVA to evaluate the consistency of the measurement results (anterior and posterior corneal curvature, corneal refractive index, CCT) obtained by CASIA2 and Pentacam.Finally, the ultimate outcome（such ad：K1 K2 KMax CCT） indicates that the P-value between the two devices is less than 0.05 and ICC-value is more than 0.75. |
Countries
China
Contacts
Primary ContactShuangcheng Li, Master
Outcome results
None listed