Intestinal Inflammation, Rhinosinusitis
Conditions
Brief summary
The goal of this observational study is to define the prevalence of chronic rhinosinusitis in patients with intestinal bowel disease. The main questions it aims to answer are: * Evaluate the influence of chronic rhinosinusitis on the quality of life of patients with intestinal bowel disease * Evaluate any relationships between chronic rhinosinusitis and the clinical course of intestinal bowel disease -Evaluate the influence of chronic rhinosinusitis on the response to biologic therapies for intestinal bowel disease * Evaluate mucosal barrier damage in patients with chronic rhinosinusitis and intestinal bowel disease by collecting blood and stool samples according to clinical practice * Presence of enterotoxin sensitization to S. Aureus in patients with intestinal bowel disease * Histopathological evaluation: reevaluation of biopsy slides performed according to clinical practice will be performed in patients with chronic rhinosinusitis and intestinal bowel disease in order to quantify the proportion of eosinophilic infiltrate at the intestinal level and to assess any differences from the population with intestinal bowel disease only. Patients with intestinal bowel disease afferent to our outpatient chronic inflammatory bowel disease clinic at CEMAD will be enrolled.
Interventions
OTHERObservational study
the aim of the study is to define the prevalence of rhinosinusitis cronic in intestinal bowel disease patients, to assess how it affects the patient's quality of life, and any correlations between these two entities
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Eligibility Criteria Inclusion Criteria: * Age between 18 years and 70 years. * Diagnosis of Crohn's disease or Ulcerative Rectocolitis * Willingness to participate in the study and ability to comply with and understand the study protocol. * Patients with a previous diagnosis of Crohn's disease or Ulcerative Rectocolitis for at least 3 months prior to screening * Signature of informed consent
Exclusion criteria
* Age \<18 years * Refusal of informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of chronic rhinosinusitis in patients with chronic inflammatory bowel disease | 1 hour | To define the prevalence of chronic rhinosinusitis in patients with chronic inflammatory bowel disease |
Outcome results
None listed