Diet, Healthy, Endotoxemia
Conditions
Brief summary
The aim of the present study is to determine the effects of different standardized dietary patterns on general health markers, intestinal function, immune response and affective processes/ cognitive skills in healthy subjects.
Interventions
OTHERDietary intervention
Participants receive diets following different dietary patterns for 1 week.
Sponsors
University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 18.5 kg/m² und 24.9 kg/m²
Exclusion criteria
* Chronic inflammatory diseases * Metabolic diseases * Viral or bacterial infections in the last 3 weeks * Allergic reactions in the last 3 weeks * Intake of anti-inflammatory drugs * Malignant diseases * Pregnancy and lactation * Smoking * Alcohol consumption \> 10 g/d for women and \> 20 g/d for men * Drug consumption * Vegetarian or vegan diet * Food intolerances
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in parameters of intestinal barrier function | 1 week | Changes in TLR ligand serum levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in parameters of immune response | 1 week | Changes in concentration of Interleukin-6 in cell culture supernatant of stimulated immune cells |
| Changes in blood lipid levels | 1 week | Changes in triglyceride, cholesterol levels \[mg/dl\] |
| Changes in cognitive skills | 1 week | Assessment of cognitive processes using computer-based psychological tasks (Stroop effect; calculation of differences in response times to incongruent vs. congruent word-color associations) |
Countries
Austria
Outcome results
None listed