Intracranial Aneurysm
Conditions
Keywords
intracranial aneurysm, surgery, neurosurgery, endovascular, interventional neuroradiology, neurointervention, unruptured
Brief summary
A research-initiated prospective cohort study with the aim to assess the effectivity, safety and long-term outcomes after surgical and endovascular treatment of unruptured intracranial aneurysms. All consecutive patients with a non-ruptured intracranial aneurysms treated at Helsinki University Hospital will be included. Safety is measured by postoperative magnetic resonance imaging (MRI) taken 1-3 days after the treatment, treatment-related complications and functional outcome at three months. Effectiveness is measured by angiographic results and assessment of long-term bleeding from the treated aneurysm. Other outcomes include risk of developing epilepsy, getting a new stroke, and dementia on long-term follow-up.
Interventions
PROCEDURESurgery
Surgical treatment for the unruptured intracranial aneurysm
PROCEDUREEndovascular
Endovascular treatment for the unruptured intracranial aneurysm
Sponsors
Helsinki University Central Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* All patients with an unruptured intracranial aneurysm undergoing treatment
Exclusion criteria
* Arteriovenous malformation related intracranial aneurysm * Moyamoya-disease related intracranial aneurysm * Ruptured intracranial aneurysm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| New ischemic lesion on postoperative MRI | 1-3 days | Diffusion-Weighted Imaging lesion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Return to work | 3 months | Days from intervention to return to work |
| Functional outcome | 3 months | modified Rankin Scale (mRS going from 0 \[no sympyoms\] to 6 death\]) |
| Aneurysm occlusion on angiography | 6mo - 5yrs | Rate of occluded vs. incompletely occluded aneurysms. Assessed through digital subtraction angiography, CTA or MRA. Routine controls for endovascularly treated patients 6mo, 2y, and if needed 5y. Routinely assessed by a postoperative CTA for surgically treated patients. |
| Neurological symptom | 3 months | New procedure-related neurological symptom |
| Epilepsy | up to 10 yrs | Number of patients with a new diagnosis of epilepsy after aneurysm treatment |
| Dementia | up to 10 yrs | Number of patients with a new diagnosis of dementia after aneurysm treatment |
| Other stroke than aneurysm bleed | up to 10 yrs | Number of patients with a new stroke (other than SAH from the treated aneurysm) after aneurysm treatment |
| Patients with late rebleeding from the target aneurysm | up to 10 yrs | Number of patients with rebleeding (subarachnoid hemorrhage \[SAH\]) from the treated aneurysm |
Countries
Finland
Outcome results
None listed