The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula

Determination of the Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula Due to Moderate and Severe Respiratory Distress

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06146439

Enrollment

201

Registered

2023-11-24

Start date

2018-10-01

Completion date

2020-02-01

Last updated

2023-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High-flow Nasal Cannula, Respiratory Distress, Treatment Failure

Keywords

Pediatric, HFNC, Respiratory distress, predictor of failure

Brief summary

The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients. The main questions it aims to answer are: * What factors contribute to the failure of HFNC treatment in these children? * What is the frequency of HFNC treatment failure in children with moderate and severe respiratory distress? Researchers will compare the group whose HFNC treatment was successful with the group whose HFNC treatment failed to identify factors that cause treatment failure.

Detailed description

Oxygen therapy with a high-flow nasal cannula (HFNC) is a well-tolerated, relatively new, non-invasive alternative ventilation treatment modality. On the other hand, HFNC failure delays advanced respirator supportive treatments, prolongs hospitalization in the intensive care unit, and emergency department, and causes a significant increase in morbidity and mortality with hypoxemia, neurological impairment, and/or hemodynamic instability. The investigators aimed to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

1 Months to 18 Years

Healthy volunteers

Inclusion criteria

* Moderate to severe respiratory distress * Oxygen therapy with high-flow nasal cannula

Exclusion criteria

* Chronic lung disease (those with CO2 retention or hypoxia in their daily life) * Cyanotic congenital heart disease * Craniofacial malformation * Trauma patients * Hypotonic patients * Cases with tracheostomy * Patients using HFNC therapy for respiratory support after extubation

Design outcomes

Primary

Measure	Time frame	Description
HFNC treatment outcome (failure or success)	30 days	Whether advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) are needed

Countries

Turkey (Türkiye)

Outcome results