Infertility
Conditions
Keywords
Infertility, IVF-ET, HCG trigger, Double trigger
Brief summary
The aim of this study is to compare the efficacy double trigger \[ co-administration of GnRH agonist with HCG 40 and 34 h prior to ovum pick-up, respectively\] with HCG trigger in inducing oocyte maturation.
Detailed description
Several studies revealed that the double trigger regimen was effective in the treatment of patients with a history of immature oocytes retrieved or with suboptimal oocytes yield. The investigators designed this randomized controlled trial to compare the efficacy double trigger with HCG trigger in inducing oocyte maturation.in normoreponders undergoing IVF-ET
Interventions
DRUGDouble trigger
GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) and hCG ( 10000 IU) are administered 40 and 34 h before ovum pick-up
DRUGHCG trigger
hCG ( 10000 IU) is administered 36 h before ovum pick-up
Sponsors
Bedaya Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Normoresponders * GnRH antagonist cycles
Exclusion criteria
* BMI more than 35 * Endometriosis * AMH less than 1.1 ng * AMH more than 4 * PCOS * Poor responders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metaphase-II oocytes rate | Ten to fifteen days after starting ovarian stimulation | Number of MII oocyte/ number of cumulus oocyte complex |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 5 weeks after embryo transfer | Presence of intrauterine gestational sac detected by transvaginal ultrasound |
| Ongoing Pregnancy Rate | 18 weeks after embryo transfer | Pregnancies continued beyond 20 weeks gestation |
Countries
Egypt
Contacts
Primary ContactUsama M Fouda, Prof.
Outcome results
None listed