Branch Retinal Vein Occlusion
Conditions
Brief summary
Several studies have indicated a relation between the development of RVO and elevated intraocular pressure (IOP) and glaucoma \[9\]. Further investigations into the structural alterations in the fellow eyes of individuals with unilateral RVO have revealed that the pRNFL is thinner than in healthy eyes, suggesting that there may be systemic risk factors for both RVO and glaucoma
Interventions
DRUGaflibercept (2mg/0.05ml)
Aflibercept is a medication used to treat and manage neovascular age-related macular degeneration, diabetic macular edema, myopic choroidal neovascularization, macular edema associated with retinal vein occlusion, and diabetic retinopathy. It is in the vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) antagonist class of medications. Aflibercept acts as a soluble protein decoy for VEGF receptors to inhibit the predominant signaling pathway responsible for angiogenesis and vascular leakage. Aflibercept and other anti-VEGF inhibitors have become the gold standard in controlling neovascular (wet) age-related macular degeneration (NVAMD). T
Sponsors
Al-Azhar University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
47 Years to 68 Years
Healthy volunteers
Yes
Inclusion criteria
* patients with unilateral BRVO
Exclusion criteria
* History of retinal and/or optic nerve diseases involving glaucomatous optic disc, ischemic optic neuropathy, or optic neuritis. * History of trauma, intravitreal injections, vitreoretinal surgeries, and retinal or macular lasers. * A significant media opacity that makes it difficult to capture clear images. * No history of diabetes and/or hypertension in those recruited as the control group
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| peri-papillary retinal nerve fiber layer thickness | Base line | Layer of the retina. The thickness was measured by Optical Coherence Tomography |
Countries
Egypt
Outcome results
None listed