Interstitial Lung Disease
Conditions
Brief summary
The goal of this observational study is to examine clinical utility of 18F-FAPI-RGD PET/CT imaging in evaluating connective tissue disease-associated interstitial lung disease. Participants will undergo clinical evaluation and 18F-FAPI-RGD PET/CT examination.
Detailed description
Interstitial lung disease is an overarching term for a wide range of disorders characterized by inflammation and/ or fibrosis in the lungs. Interstitial lung disease associated connective tissue diseases(CTD-ILD) is one of the most common types.The goal of this study is to explore the feasibility of using 18F-FAPI-RGD, a dual-targeting heterodimeric PET tracer that recognizes both fibroblast activation protein (FAP) and integrin αvβ3 for detecting connective tissue disease associated interstitial lung disease (CTD-ILD), and analyze the relationship between 18F- FAPI-RGD PET/CT images and related parameters of lung function, clinical laboratory indicators and HRCT scores.
Interventions
None listed
Sponsors
Sichuan Provincial People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 and above * Patients who have been diagnosed with, or are clinically highly suspected of ILD * Patients who have been diagnosed with, or are clinically highly suspected of CTD-ILD
Exclusion criteria
* Pregnant or breastfeeding * Patients with tumor, other respiratory diseases, and lung surgery * Abnormal cardiopulmonary function or mental state, unable tolerate PET/CT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between clinical indicators and PET/CT results | 2 months | Correlation of clinical pulmonary function indexes, HRCT, laboratory examination indexes and 18F-FAPI-RGD PET/CT results |
Countries
China
Outcome results
None listed