Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
Through the clinical observation of Qingcheng Pingxian Granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease (phlegm-heat lung syndrome), (1) to evaluate the safety of Qingcheng Pingxian Granules in the acute exacerbation of chronic obstructive pulmonary disease; (2) to observe the clinical efficacy of Qingcheng Pingxian Granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease, to provide an effective medication and solution for the treatment of acute exacerbation of chronic obstructive pulmonary disease, and to provide data for the development of the further application of Qingcheng Pingxian Granules.
Interventions
DRUGQingkepingchuan Granules
Qingkepingchuan Granules,Take it three times a day with water after meals.
OTHERconventional treatment
Oxygen intake, selection of appropriate antibiotics based on lab results, and other treatments
Sponsors
Zhang Zhijie
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Qingkepingchuan Granules
Eligibility
Sex/Gender
ALL
Age
40 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Meet the diagnostic criteria of AECOPD. 2. Chinese medicine diagnosis is consistent with phlegm-heat and lung depletion evidence 3. 40 years old ≤ age ≤ 90 years old 4. Patients who signed the informed consent form and volunteered to participate in the study
Exclusion criteria
1. Combined with other primary lung diseases such as bronchial asthma, bronchiectasis, etc. 2. Combination of serious cardiovascular, urinary, digestive, haematopoietic, endocrine metabolic system diseases, other psychiatric and neurological diseases. 3. Pregnant or lactating patients. 4. Allergic to the clinical trial drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Chinese Medicine Symptoms Scale | Before the start of treatment, 1 week of treatment, 2 weeks of treatment, 1 month of follow-up | Record changes in patients' TCM indicators。The scale includes cough, wheezing, shortness of breath, sputum volume, chest tightness, sputum colour, sputum quality, fever, thirst, irritability, constipation, tongue coating, and pulse. The first four items are rated 0-6, and the last nine items are rated 0-3, with higher ratings indicating poorer treatment outcomes. |
| COPD assessment test | Before the start of treatment, 1 week of treatment, 2 weeks of treatment, 1 month of follow-up | Record changes in the patient's condition |
| breathlessness measurement using the modified British Medical Research Council | Before the start of treatment, 1 week of treatment, 2 weeks of treatment, 1 month of follow-up | Record changes in the patient's condition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6-minute walking test | Before the start of treatment, 2 weeks of treatment | Record changes in the patient's condition |
Countries
China
Outcome results
None listed