Fluid Responsiveness, Stroke Volume Variation, SVV-FloTrac, Thoracic Electrical Bioimpedance
Conditions
Brief summary
Stroke volume variation (SVV) is an indicator used to assess the patient's volume status. The FloTrac system (Edwards Lifesciences, Irvine, CA) continuously monitors cardiac output (CO) and SVV (SVV-FloTrac) by analyzing the systemic arterial pressure wave. Numerous studies have demonstrated that SVV-FloTrac serves as a reliable indicator of fluid responsiveness. However, its peripheral invasiveness raises concerns about susceptibility to reflecting waves, damping, and vascular tone influences.In contrast, Transthoracic electrical bioimpedance (BioZ.com™) offers a non-invasive approach for continuously monitoring various hemodynamic variables. In this study, the primary aim was to assess the agreement between simultaneously measured SVV-FloTrac and SVV-BioZ.
Interventions
DEVICEFlotrac Group
Haemodynamic parameters were collected simultaneously by the Flotrac monitoring.
DEVICEBioZ Group
Haemodynamic parameters were collected simultaneously by the thoracic bioimpedance (BioZ.com™)monitoring.
Sponsors
RenJi Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18≤ Age ≤65. * patients undergoinglaparoscopic elective surgery for gastrointestinal tumors under general anesthesia * 18 kg/m2≤BMI≤30 kg/m2 * ASA classification I-III * Patients signed informed consent form
Exclusion criteria
* Arrhythmias * The patient is diagnosed with severe cardiovascular disease（pulmonary arterial hypertension、left ventricular ejection fraction\< 50%、aortic aneurysm、extensive peripheral arterial occlusive disease,、significant valvulopathy） * Severe heart failure (METS\<4) * The patient is diagnosed with severe hepatic dysfunction (ChildePugh class C) * The patient is diagnosed with severe renal dysfunction (undergoing dialysis before surgery) * There is an infectious lesion on the skin or subcutaneous tissue where the non-invasive electrode piece is placed * History of allergy to anesthetic drugs * Weight\<40kg * Allergies to 6% hydroxyethyl starch, Fresenius Kabi, Deutschland
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The agreement between simultaneously measured SVV-FloTrac and SVV-BioZ | From anesthesia induction to the nonresponsive VLS about one hour. | After anesthesia induction, volume loading was initiated. For each volume loading step (VLS), 100 mL of colloid solution (6% hydroxyethyl starch) was administered over a 2-minute duration. The SVV was measured and recorded simultaneously by FloTrac (SVV-FloTrac) and Transthoracic electrical bioimpedance(SVV-BioZ). Volume loading steps (VLS) continued until no responsive VLS was observed. Responsive VLS, defined as an increase in Flotrac-SV by at least 5%, and nonresponsive VLS, characterized by no change or an increase in Flotrac-SV by less than 5%, were subsequently identified. Multiple analysis methods were used to determine the agreement of the two SVVs. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The capacity to predict fluid responsiveness. | From anesthesia induction to the nonresponsive VLS about one hour. | After anesthesia induction, volume loading was initiated. For each volume loading step (VLS), 100 mL of colloid solution (6% hydroxyethyl starch) was administered over a 2-minute duration. The SVV was measured and recorded simultaneously by FloTrac (SVV-FloTrac) and Transthoracic electrical bioimpedance(SVV-BioZ). Volume loading steps (VLS) continued until no responsive VLS was observed. Responsive VLS, defined as an increase in Flotrac-SV by at least 5%, and nonresponsive VLS, characterized by no change or an increase in Flotrac-SV by less than 5%, were subsequently identified. Multiple analysis methods were used to determine the capacity to predict the fluid responsiveness of these two devices. |
Countries
China
Contacts
Primary ContactDiansan Su, Dr.
Backup ContactYuwen Cheng
Outcome results
None listed