Acne Vulgaris
Conditions
Keywords
acne, non-cystic acne, mild to moderate acne
Brief summary
The purpose of this study is to determine the effects of using silk pillowcases in mild to moderate non-cystic acne prone skin in comparison to cotton pillowcases.
Detailed description
The investigators will evaluate acne severity/ lesion count, trans-epidermal water loss, and sebum production in participants. There is an equal chance of being assigned a 100% silk pillowcase or 100% cotton pillowcase.
Interventions
OTHERSilk Pillowcase
100% Mulberry Silk Pillowcase
OTHERCotton Pillowcase
100% Cotton Pillowcase
Sponsors
Integrative Skin Science and Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and females between the ages of 15-45 years of age * The presence of mild to moderate acne vulgaris based on investigator global assessment * Presence of at least 5 inflammatory lesions and at least 5 non-inflammatory lesions
Exclusion criteria
* The presence of severe acne as noted by investigator global assessment. * Those who are unwilling to discontinue systemic antibiotics and benzoyl peroxide for 4 weeks meet the washout criteria prior to enrolling. * Those who are unwilling to keep their facial regimen consistent throughout the study, and for 1 month prior to enrolling. * Individuals who are unwilling to wash pillowcase every week using provided detergent. * Use of isotretinoin within the three months prior to enrolment * Individuals who primarily sleep on their back * Current tobacco smoker or a tobacco smoking history of greater than 10 pack year * Individuals on oral contraceptive pills or progesterone or estrogen containing therapies. * Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study * Individuals with known allergy or sensitivity to Mulberry Silk or Cotton Fibers in fabric
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acne Lesion Counts: Inflammatory Lesions | 8 weeks | The inflammatory lesion counts will be counted and compared against baseline |
| Acne Lesion Counts: Non-Inflammatory Lesions | 8 weeks | The non-inflammatory lesion counts will be counted and compared against baseline |
| Facial Erythema Intensity Score | 8 Weeks | Facial erythema will be measured as the erythema intensity score as measured by the image analysis system (BTBP 3D Pro) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin Hydration | 8 Weeks | Skin Hydration measured with MoistureMeter |
| Skin Microbiome, relative abundance of C. acnes | 8 Weeks | Changes in skin microbiome relative abundance of C. acnes will be assessed with swab based collections of the facial skin microbiome |
| Transepidermal water loss | 8 Weeks | Change in Facial Trans-epidermal Water Loss, measured with vapometer |
| Sebum Excretion Rate | 8 weeks | Shift in the facial sebum excretion rate, measured with sebumeter |
Contacts
Primary ContactAjay S Dulai, MBBS MSc
Backup ContactRaja K Sivamani, MD MS AP
Outcome results
None listed