Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Optimal Stimulation Parameters for Spike-ripple Disruption in Patients Undergoing Invasive Monitoring

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06141668

Enrollment

Registered

2023-11-21

Start date

2023-06-13

Completion date

2026-11-30

Last updated

2024-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refractory Epilepsy

Brief summary

Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

Interventions

OTHERNeurostimulation

Electrical stimulation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

\- Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation

Exclusion criteria

\- Baseline spike ripple rate \< 0.5/min.

Design outcomes

Primary

Measure	Time frame
Spike ripple rate	1-3 hours

Secondary

Measure	Time frame
Spike rate	1-3 hours

Countries

United States

Contacts

Primary ContactCatherine Chu, MD

cjchu@mgh.harvard.edu617726-6540

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026