The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy in Different Age Groups

The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitrous Oxide Synthase Salivary Levels in Different Age Groups of Chronic Periodontitis Patients (A Randomized Clinical Trial)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06140394

Enrollment

Registered

2023-11-20

Start date

2023-04-29

Completion date

2024-06-25

Last updated

2024-06-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Inflammation

Brief summary

the summary is to evaluate The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitrous Oxide Synthase Salivary Levels in Different Age Groups of Chronic Periodontitis Patients

Detailed description

2 ml of unstimulated saliva will be collected using spitting method, the collected samples will then be analyzed using Elisa technique for salivary Inducible nitrous oxide synthase levels.

Interventions

OTHERdiode laser

low level diode therapy

OTHERnon surgical scaling

non surgical scaling using ultrasonic

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

60 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* males and females * aged below 40 or above 60 * periodontitis stage 2 * no tooth loss due to periodontitis

Exclusion criteria

* smoking habits * history of antibiotics * history of systemic diseases

Design outcomes

Primary

Measure	Time frame	Description
clinical parameters (gingival index)	6 months	measurement if the gingival index using scoring system. A score from 0.1-1.0 = mild inflammation; 1.1-2.0 = moderate inflammation from, and 2.1-3.0 signifies severe inflammation.
clinical parameters (clinical attachment loss)	6 months	measurement of clinical parameters clinical attachment loss in millimeters

Secondary

Measure	Time frame	Description
assessment of inducible nitrous oxide synthase levels	3 months	measurement of inducible nitrous oxide synthase levels in different age groups before the procedure and after using Elisa kit.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026