Healthy
Conditions
Keywords
meal ingestion, meal composition, postprandial responses, hedonic sensations, homeostatic sensations
Brief summary
Aim: to determine to what extent meal composition influences postprandial sensations. Experimental design: randomized cross-ower study comparing the responses to a high protein (47.3% protein, 39.4% carbohydrates, 13.3% lipids) versus a balanced (22.2% protein, 67.85% carbohydrates, 9.95% lipids). In each participant the meals (both containing 20.8 g protein and diluted to a volume of 200 mL) will be tested on separate days. Healthy, non-obese participants (8 men and 8 women) will be instructed to eat a standard dinner the day before, to consume a standard breakfast at home after overnight fast, and to report to the laboratory, where the test meal will be administered 3 h after breakfast. Studies will be conducted in a quiet, isolated room with participants sitting on a chair. Perception will be measured at 5 min intervals 10 min before and 20 min after ingestion, at 10 min intervals up to 60 min after the meal and at 30 min up to 120 min after ingestion. Blood samples for biochemical and hormonal determinations will be taken before and after ingestion.
Interventions
OTHERHigh-protein supplement
High protein supplement 200 mL
OTHERBalanced supplement
Balanced supplement 200 mL
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* non-obese
Exclusion criteria
* history of gastrointestinal symptoms * prior obesity * use of medications * history of anosmia and ageusia * current dieting * alcohol abuse * psychological disorders * eating disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in digestive well-being measured after the test meal | 1 day | Change in average well-being measured by 10 score scales at the end of the test meal. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in satiety measured after the test meal | 1 day | Change in average satiety measured by 10 score scales at the end of the test meal |
| Change in fullness sensation measured after the test meal | 1 day | Change in average fullness measured by 10 score scales at the end of the test meal |
| Change in abdominal discomfort/pain sensation measured after the test meal | 1 day | Change in average abdominal discomfort/pain measured by 10 score scales at the end of the test meal |
| Change in mood measured after the test meal | 1 day | Change in average mood measured by 10 score scales at the end of the test meal. |
Countries
Spain
Contacts
Primary ContactFernando Azpiroz, MD
Backup ContactGloria Santaliestra
Outcome results
None listed