Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06138574

Acronym

Effects of Dex

Enrollment

Registered

2023-11-18

Start date

2023-12-01

Completion date

2024-03-30

Last updated

2023-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty Surgery

Brief summary

Our aim in this treatment was to reveal the effects of remifentanil and dexmetomidine, which we used to provide controlled hypotension in septorhinoplasty surgery, on cardiac electrophysiology. We planned to compare the patients by recording preoperative and postoperative ECGs. We also planned to record the patients' intraoperative blood pressure, saturation, and pulse rate, rickeragitation scale, and vas score.

Interventions

DRUGDexmedetomidine

After the induction of general anesthesia, one group (Group: 1) will be administered dexmedotomidin infizyon and group (Group :2)remifentanil

DRUGRemifentanil

Remifentanil

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

17 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* patients with an ASA score of I and between the ages of 17-45 years, who were to undergo general anesthesia with sevofulurane were included in the study.

Exclusion criteria

Patients aged \<17 and \>45 years, patients with liver and/or kidney failure, obese patients (BMI \>30), trauma patients, ASA II-III-IV patients, patients with bleeding disorders, those using drugs that may affect the coagulation system, patients with cardiomyopathy, cerebrovascular disease, immobility, and malnutrition were excluded from the study. \-

Design outcomes

Primary

Measure	Time frame	Description
iceb	preoperative and postoperative (immediatly after extubation)	Qt\\Qrs

Secondary

Measure	Time frame	Description
Riker Agitation Scale	Immediately after extubation	7 -Dangerous Agitation, 6 - Very Agitated, 5 - Agitated, 4 - Calm and Cooperative, 3 - sedated, 2- Very Sedated, 1 -Unarousable
mean arterial pressure	when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubasion	mmHg
heart rate	when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubasion	beats\\minute
Numeric Rating Scale	Postoperative 0-2 hours	They will be numbered from 1 to 10. 1 mildest 10 most severe pain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026