Brain Network Connectivity, Postoperative Delirium, Dexmedetomidine, Propofol
Conditions
Brief summary
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Interventions
DRUGDexmedetomidine
Participants will be sedated and maintained by dexmedetomidine during the surgery.
DRUGPropofol
Participants will be sedated and maintained by propofol during the surgery.
Participants will be sedated and maintained by remimazolam during the surgery.
Sponsors
Beijing Tiantan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosed as unilateral supratentorial glioma by MRI * Selective operation * Age over 18 years old * ASA I-II * Right handedness
Exclusion criteria
* History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs * History of intracranial surgery * Drug and/or alcohol abuse * History of dementia or mental illness * Pregnant or lactating women * Contraindications for MRI * Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block * Severe hepatic or renal dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The alterations of brain network connectivity. | Before sedation, 30 minutes after sedation，and 30 minutes after surgery. | fMRI and DTI will be used to detect brain network connectivity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative delirium. | Day 1-5 after surgery. | The incidence and severity of postoperative delirium and its association with changes of brain network connectivity. |
| Electroencephalogram changes | From patients admission to operation room until 10 minutes after surgery | Electroencephalogram will be used to record the brain activity. |
| rScO2 changes. | From patients admission to operation room until 10 minutes after surgery | Regional cerebral oxygen saturation (rScO2) will be monitored with near-infrared spectroscopy (NIRS). |
Countries
China
Contacts
Primary ContactYuming Peng, MD,Ph.D
Outcome results
None listed