Chronic Total Occlusion, Coronary Artery Disease
Conditions
Brief summary
This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
Detailed description
Coronary artery disease (CAD) is still one of the major contributors to global mortality. CTO is a special lesion type of CAD, defined as complete occlusion of at least one major epicardial coronary artery more than 3 months. Compared to non-CTO patients, those with CTO have worse prognosis. The prognosis of CTO patients is related to many factors including the baseline characteristics, modality of treatment and the degree of coronary collateral formation. Figuring out the factors which can indicate the outcomes of CTO is essential to clinical decision making. In this single center, observational study, we collect patient's clinical characteristics and blood samples to investigate potential factors associated with the development of coronary collateral formation and outcomes in patents with stable coronary artery disease.
Interventions
PROCEDURECoronary angiography
Sponsors
Ruijin Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age ≥18 years; Patients with angina or silent ischemia and documented ischemia; Patients with CTO ≥ 3months
Exclusion criteria
* eGFR\<15mL/(min·1.73m2); Chronic heart failure with NYHA grade ≥3; Had a history of coronary artery bypass grafting; Had received a percutaneous coronary intervention within the prior 3 months; Malignant tumor or immune system disorders; Pulmonary heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The degree of collateral estimated visually by Rentrop score during coronary angiography | Immediate post-angiography | The degree of coronary collateralization supplying the distal area of the total coronary occlusion was visually graded using the Rentrop scoring system as follows: 0=no visible collaterals; 1=poorly opacified collaterals with faint visualization of the distal vessel; 2=partial filling of the collateral vessels; and 3=complete filling of the collateral vessels. Patients were then classified as poor coronary collaterals (Rentrop scores of 0 and 1) or good coronary collaterals (Rentrop scores of 2 and 3), according to the Rentrop score. |
| Composite event of all-cause mortality, non-fatal myocardial infarction, heart failure and repeat revascularization | up to 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Event of all-cause mortality | up to 5 years |
| Event of death from cardiac causes | up to 5 years |
| Event of heart failure | up to 5 years |
| The change of left ventricular ejection fraction | 1 year |
| Events of repeat revascularization | up to 5 years |
| Event rate of procedural success | Immediate post-PCI |
| Event of procedural outcomes | 1 month post-angiography or PCI |
Countries
China
Contacts
CONTACTFenghua Ding, PhD, MD
STUDY_CHAIRFenghua Ding, PhD, MD
Ruijin Hospital
Outcome results
None listed