Dermal Regeneration
Conditions
Brief summary
Dermogenesis With Mesenchymal Stem Cells in treating Post Acne Depressed Spots
Detailed description
management at two different stages of the course of the disease. First one at the stage of active disease which needs cleansers, antibiotics, retinoids, anti inflammatory agents and hormonal manipulation. Once active disease is over, patients report to clinician with depressed spots which are caused by localized dermal disruption and fat atrophy post inflammation or spontaneous epithelial rupture or scratching by the patient. These acne spots are hard to treat due to many reasons. Firstly, excision is difficult as size of most of them is small and they are in a large in number. Secondly, filling with and without subcision is not adequately addressing the deformity. Currently, a combination of filling with synthetic filler or fat and resurfacing by peeling, LASER or dermabrasion is in practice. In-spite of all, a treatment is still required to address post acne spots (Ice Spec Spots) adequately.
Interventions
PROCEDUREAutologous Mesenchymal stem cells injection
Autologous Mesenchymal stem cells will be seperated from harvested fat and injected in acne scars
PROCEDUREHomogenized fat injection
Autologous fat will be harvested, homogenized and injected.
Sponsors
King Edward Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Group A with MSCs Group B with Fat
Eligibility
Sex/Gender
ALL
Age
No minimum to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Acne spots
Exclusion criteria
* Active acne
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dermal thickness | 3 months | on microscopy of biopsy section |
Countries
Pakistan
Outcome results
None listed