Titanium Prepared Platelet-rich Fibrin in Bone Regeneration in Lateral Window Maxillary Sinus Augmentation

Evaluation of Titanium-prepared Platelet-rich Fibrin in Bone Regeneration in Lateral Window Maxillary Sinus Augmentation (Clinical Trial)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06135077

Enrollment

Registered

2023-11-18

Start date

2021-11-11

Completion date

2023-03-21

Last updated

2023-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sinus Lifting

Brief summary

This trial aims to evaluate the effect of the sole use of T-PRF in bone formation process as applied in maxillary sinus floor elevation in comparison to traditional T-PRF/bone graft combination. This study is clinical trial that will include 18 patients seeking implant placement in upper posterior maxilla compromised with maxillary sinus pneumatization. Patients will be assigned into control and test groups. All the patients will undergo sinus lifting procedure through which a combination of xenograft and T-PRF was used in the control group whereas; sole T-PRF will be applied in the test group.

Interventions

OTHERT-PRF alone

T-PRF is the material to be tested in this study as an alternative to classical bone graft

OTHERT-PRF/Xenograft

One part of T-PRF will be divided into minute pieces to be mixed with xenograft

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Months to No maximum

Healthy volunteers

Inclusion criteria

* Systemically in a healthy condition. * Residual bone height is ≤5mm in the posterior maxilla as measured with CBCT. * Non-smokers. * Good oral hygiene as indicated by plaque and bleeding scores

Exclusion criteria

* Medically compromised conditions will be excluded to avoid infections or any adverse reaction related to immunity suppression. * Acute maxillary sinusitis. * Patients administering any antibiotics or regular anti-inflammatory drugs.

Design outcomes

Primary

Measure	Time frame	Description
Change in pain level	up to 2 weeks	measuring level of pain using visual analog scale (VAS) 0-10, where 0 reading indicates no pain and 10 reading reflects the most severe pain.
Change in bone volume	up to 3 months	pre opertaive and post operative CBCT
Change in bone denisty	up to 3 months	pre opertaive and post operative CBCT
Change in bone height	up to 3 months	pre opertaive and post operative CBCT

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026