Non-Functioning Kidney, Renal Cell Carcinoma
Conditions
Brief summary
Laparoscopic nephrectomies are commonly performed these days and are considered gold standard for both benign and malignant diseases as well as for donor nephrectomies. Despite being a widely performed surgery worldwide still there are areas of uncertainties due to lack of evidences. One of such area of dilemma is the optimum pressure of pneumoperitoneum. This study aims to identify if lower pressure of pneumoperitoneum is safe during laparoscopic nephrectomies. This is a hospital based prospective randomized control study. All the patients undergoing laparoscopic nephrectomies at department of urology and kidney transplant surgery will be eligible for study. Patients will be divided into low pressure or standard pressure pneumoperitoneum by simple random sampling and comparison of various intraoperative and post-operative parameters will be done to assess the safety of low pressure pneumoperitoneum
Interventions
PROCEDURELaparoscopic Surgery
* Surgery will then proceed at either 8 - 10 or 12 - 15 mmHg pneumoperitoneum pressure depending on study group the patient falls into * Port Placement * Reflection of colon * Isolation of ureterogonadal packet * Upper pole dissection * Hilar dissection * Vessel clipping and division * Dissection of kidney * Delivery through either Pfannenstiel or iliac fossa incision
Sponsors
Institute of medicine, Maharagjung medical campus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Masking description
Participants will be blinded.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients undergoing laparoscopic nephrectomy
Exclusion criteria
* Age \<18 years * History of previous abdominal surgeries * Laparoscopic donor nephrectomies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare the safety of low pressure versus standard pressure pneumoperitoneum in laparoscopic nephrectomy | 30 days perioperative period | Complications between two groups will determine the safety of procedure. |
| To compare the efficacy of low pressure versus standard pressure pneumoperitoneum in laparoscopic nephrectomy | 30 days perioperative period | Operative time will help to determine efficacy of treatment. |
Outcome results
None listed